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AIMS OF
THE STUDY
Mandatory clinical and technical aspects for the success of the painless urethral
techniques for diagnostics and the tharapy possibilities of different lower
urinary tract dysfunction have been never studied enough. Some very interesting
historical findings from the most prominent world experts in neurology and neurophysiology
in the past have misled us completely and gave us no hope for the routine urodynamics.
It has been believed, that surface urethral and bladder EMG, needing to be painless
and thus routinely applicable in every day urodynamics, were just not right
and had no clinical value. Only the needle or wire EMG detection has been what
it has been applicable and reliable in the case of the urethra and bladder.
They did not know that the technical aspects were not solved satisfactorily
in 80's, that this had been the only reason for the noisy urethral surface EMG
signal, they were able themselves to detect in the urethra. The rest were trying
to use the surface technique, but unfortunately they were instead of using urethral
sphincter and urethral wall to detect the EMG from, they used the vaginal or
anal entrance. This again was missing the point, as the other muscles having
different function lay around and not primarily the urethral and bladder neck
closing / delivering musculature, being mostly reflex and autonomously controlled.
As we have gained as well new knowledge about the importance of the smooth muscle
component beside striated muscle part on one side and on the other side dared
to use high quality modern electronic components, the times have changed.
MATERIALS AND
METHODS
The neuromuscular subsystem is without any doubts the main active part of the
lower urinary tract function. To approach this subsystem when necessary in routine
urodynamics and objectively evaluate the reasons for its dysfunction, we have
to use the quantitative user-friendly neurophysiological EMG techniques. The
basic promising findings using surface urethral EMG has been known for some
tens years (1), and yet nobody had wanted to apply or better to consider the
idea and contact us. The main idea® behind, Muscle Activation Function (MAF),
which had to be understood first, was given on the ICS in London (2). Since
then we have been using this idea more and more elsewhere (3). The final application
with better EMG sensor® for the lower urinary tract has been given in 1997
(4), when the real time joint time/frequency analysis of the obtained EMG interference
pattern©, introduced the applicability of this surface urethral EMG technique
also for portable machinery. The comparatory needle EMG has been performed in
each patient, proving that the surface EMG interference pattern gives a better
information and idea about the storing/closing function of the urethral wall
in men.
RESULTS
Standard urodynamic pressure-flow gas micro tip pressure catheter measuring
system has been used. Figure 1 shows the 4 channels urethral EMG, applied with
equidistantly positioned longitudinally strips-electrodes placed on this catheter
of size F8. The 4- channel EMG patterns measured within the female urethra in
the place of the maximal closing pressure position in an MS female patient during
voiding are given. A spastic, hyperactive pattern is found. The bladder-sphincter
dissynergia was the cause for the trouble in this female patient, being not
able to void normally and ever completely empty the bladder. Further in Figure
2 the stress incontinent MS patient during voluntary retention and coughing
(partially in Figure 3) the urinary stream or very week and too slow activation
of the closing fast striated muscle fibres. The frequency analysis in the frequency
plot (Figure 3, left) demonstrated clearly the absence of the fast frequencies
above 120 Hz 8 (first right plot), meaning that the fast striated muscle fibres
have been absent and no reflex recruitment, being necessary in the stress situations,
the striated reflex neural control had been damaged. On the other side the increase
in lower frequencies recruitment demonstrated that the smooth muscles activation.
Figure 1: Hyperactive urethral sphincters (4 channel EMG interference pattern) in an MS patient with urinary hesitancy during voiding - (down first left picture)
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Mild Stress inc. |
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COUGHING |
Figure 2: in nearly normal MS patient during rest ( upper middle left) and during holding the urine ( upper middle right) and the mild stress incontinent not neurogenic patient ( lower part of the upper right paper recordings) and normal during coughing ( upper part of the upper right recordings)
Figure 3: last upper right photo
DISCUSSION AND
CONCLUSIONS
Urethral innovative multi-channel Pt- electrodes sensor® has been equipped
with necessary micro tip pressure sensors and everything else has been just
technologically known from before (2). The noise free EMG interference pattern
of some micro volts became for us the main method to judge upon the neuromuscular
function (3, 4), i.e. striated fast twitch and tonic as well as smooth muscle
fibres contribution to the harmony in coordination and proper function of the
lower urinary tract during storing, voiding and treatment procedures But the
main clinical findings in men and women, children and babies with different
dysfunction in the lower urinary tract had to be reviewed and altogether with
the known demands in the technical part, a new, totally new technology had to
be developed for the purpose of the new routine, simple and reliable surface
EMG technique. 20 years of the hard research and development work described
here gives us to judge whether it is worth at last to trust to the growing clinical
expertise and understanding supporting this technique in Slovenia, England,
Norway, Germany, Denmark, Holland and elsewhere. The urodynamics and X-rays
video voiding has been in the recent year considerably improved. But the neurophysiology,
being the main technique to get the neuromuscular diagnosis, has suffered a
big lack. The needle EMG has given an insight only in very special cases - i.e.
female adults. But the main male patients group with prostata problems and urinary
obstruction have still not had the right routine technique, which would help
to see the presence of the normal and not hyperactive tonic urethral EMG in
prostata obstruction cases. The needle EMG is very much lacking in those cases,
as it is difficult to position the needle and to split in the EMG signal being
detected the tonic and denervation muscle potentials or hyperactive potentials
towards the voluntary and reflex activation of the sphincter during stress situations,
during the bladder filling and during voiding. The so-called bladder-sphincter
dissynergia has not been measured together with urodynamics on pressure-flow
studies routinely, being very important not to operate too many times as false
positive, as it is the growing tendency. As the neuromuscular obstruction has
to be objectively excluded, before we should operate such an obstruction, this
will be the case if applying the presented EMG technique. Our method of the
surface painless EMG is the future, which will be bright for many poor male
patients of all ages and status with lower urinary tract disorders. They have
got a perfect and nearly foolproof method now. But the children population of
the neurogenic bladder will get the first usable methodology to be applied to
find anything about their neurophysiological information.
REFERENCES
(1) In: Female Incontinence, N.Zinner, A.M.Sterling(Eds.),Alan R.Liss.Inc, New
York,1981, pp 299-306.
(2) Proc. 15 Annual Meet ICS, London, 1985, pp.48-49.
(3) J.EEG & Clin Neuroph,Vol61/3,1985, p.596.
(4) Proc. 25 Annual Meet. ICS, Tokyo, 1997, p.24.
(5) University of Ljubljana/Oslo, 1992, book, 350 pages. ÓÒPCT NO/97/00263 is
patent pending